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A total of 10 mg in an adult human should be adequate, which is about 2000 times lower than the LD50 calculated for humans

Reduced SAM levels due to methionine starvation promote the dissociation of SAM with SAMTOR and then promote the association of SAMTOR with GATOR1 to repress the mTORC1 pathway

Cell death & disease 4, e861 (2013)

Species-Specific Thiol-Disulfide Equilibrium Constants: A Tool to Characterize Redox Transitions of Biological Importance

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