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Description
Still, high doses could have some side effects, like dizziness, headache, anxiety, nausea, and vomiting
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35 were preclinical (animal studies)
However, increasing lipophilicity to improve brain penetration risks a dramatic reduction in solubility once in the aqueous environment of the brains interstitial fluid, and CNS-to-blood transporters further prevent drug accumulation within the brain [6]
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