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In these models, we take into account the reaction geometry of common thiol-disulfide exchange reactions and distinguish hypothetical protein areas that might either interact with the disulfide substrate (a scaffold site) or the reducing agent (an activator site) (Fig

As a result of the suppressed levels of catalase, there is an increased concentration of hydrogen peroxide, which can be further decomposed to hydroxyl radicals by a photochemical reaction (Schallreuter et al

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Although it is unclear how EGFR activation modulates GPx-1 activity, the increase in activity was rapid and peaked within 15 min, suggesting an event that required activation of existing GPx-1, possibly by phosphorylation or through alterations in proteinprotein interactions