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Cathepsin B-sensitive peptide linkers, hyaluronic acid-based nanoparticles, ATP-responsive liposomes and micelles, and 4-Phenylbutyric acid-modified hyaluronic acid-based nanoparticles are engineered to release pharmaceuticals in reaction to enzyme activity, enzymatic degradation by hyaluronidase, elevated ATP levels in metabolically active tumor cells, and esterase activity in 4-PBA-modified hyaluronic acid-based nanoparticles (79)

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