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The US National Kidney Foundation did not recommend routine administration of L-carnitine to subjects undergoing dialysis yet encouraged the development of trials in patients with select symptoms that do not respond to standard therapy, i.e., persistent muscle cramps or hypotension during dialysis, severe fatigue, skeletal muscle weakness or myopathy, cardiomyopathy, and anemia requiring large doses of erythropoietin (74, 75)

Immunostaining for the astroglial marker GFAP and microglial marker OX42 was increased

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Severe hypoglycemia was shown to cause mitochondrial swelling in the brain, followed by neuronal cell death