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Vlahovicek K, Kajn L, Agoston V, Pongor S: The SBASE domain sequence resource, release 12: prediction of protein domain-architecture using support vector machines

The classification of nevi is descriptive and can contain multiple dimensions (cell of origin, location within dermis and epidermis, congenital, and acquired) that are not necessarily mutually exclusive, but can add to confusion

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All share a common core domain structure consisting of four EF hand repeats, a TIM barrel catalytic domain, separated into X and Y domains connected by a flexible X/Y insert linker, and a C2 domain (Kadamur and Ross, 2013)

C., Wang Y