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If none of these tests reveal underlying gut dysfunction and/or you have already healed your gut, thats when its important to look to gene testing

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Methylation Capacity Second, NNMT inhibition affects cellular methylation capacity: SAM is required for hundreds of methyltransferase reactions throughout the cell, and NNMT's consumption of SAM can deplete this critical resource, while the SAH produced by NNMT is a potent product inhibitor of many methyltransferases

Treatment upregulated protein translation components and stimulated the transsulfuration pathway for oxidative stress protection, with no reported adverse events (Dimet-Wiley et al., 2024)

These findings suggest that the relationship between MTHFR genetic variants and MS remains unclear [102, 103]