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Vitamin B 12 -responsive severe leukoencephalopathy and autonomic dysfunction in a patient with normal serum B 12 levels J Neurol Neurosurg Psychiatry 2010;81:1369-71

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The dosage is pretty much standard for each child, though depending on the clinical response, we may change the frequency of the injections to maximize improvement or minimize annoying effects (below)

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The presence of rs1695 (313 A/G) creates another restriction site within the 328 bp fragment which when digested by Alw26I, yielded two fragments of 222 and 106 bp (GSTP1 Val/Val) (Fig