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Of these, Clade 3 enzymes that use NADPH as cofactor are the most widely distributedall 44 of the animal CAT enzymes we identified belong to Clade 3 and are distinct from the 15 non-metazoan sequences (Fig

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Besides genetic predisposition, the development of DPN is closely linked to diabetes control and the effectiveness of its treatment, particularly in the early years following diagnosis [16]