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Attachment Sites on the Antibodies for Linkers The main groups involved in chemical reactions in the antibody molecule are the sulfhydryl group of cysteine and the primary amino group of lysine, which participate in two reactions commonly used in random coupling ADC, namely the Michael addition reaction of sulfhydryl group and maleimide, substitution reaction of amino succinimide ester

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[DOI] [PubMed] [Google Scholar] 17.Lu M.C., Ji J.A., Jiang Z.Y., You Q.D

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