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Humans are also exposed to heavy metals through industrial operations such as foundries, smelters, oil refineries, petrochemical plants, pesticide manufacturing, and the chemical industry (Mitra et al

76,77,78,79,80 The activity of NOXs in ferroptosis is positively regulated by a kinase (e.g., MAPK14/p38) or a binding protein (e.g., dipeptidyl peptidase 4 (DPP4/CD26)) 76,80 (Fig