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The metabolism and clearance of both components may be affected by significant liver disease, and patients with severe hepatic impairment should be monitored closely if treatment is deemed necessary

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10.3109/10673229.2010.511059 [DOI] [PMC free article] [PubMed] [Google Scholar] 84.Cuccurazzu B, Bortolotto V, Valente MM, Ubezio F, Koverech A, Canonico PL, et al

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