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[PubMed] [Google Scholar] 115.Brown RP, Gerbarg PL, Muskin PR

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It is initiated by extracellular stimuli, such as interactions between death receptors and their ligands, or by intracellular signals, including pathogen-derived nucleic acids ( 2.2.1 Classical pathways of necroptosis in SA-AKI Recent research has elucidated that the canonical pathway of necroptosis involves the RIPK1/RIPK3/MLKL signaling axis