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17 The duration of treatment protocol and the number of exercise sessions per week were also extracted

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First, case-control cross-sectional studies, using DCE-MRI, have shown a widespread BBB disruption, characterized by an increased rate of leakage, higher leakage volumes or the presence of hotspot leakages, within both normal-appearing WM and WMHs, in patients with cSVD relative to age-matched controls (Figure 22) (517, 520523)

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doi: 10.1016/j.ab.2004.03.068