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Factors involved in this condition can be genetic, extrinsic or things like too much compression on the disc, nutrition disruption, injuries and overloads, as well as intrinsic or internal chemical factors

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In the case of proteins associated with glucose metabolism, loss of activity following HNE oxidative modification would lead to loss of ATP production

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High-carbohydrate refeeding after fasting increases the degradation of Keap1 through the combined actions of p62/SQSTM1 and sestrin-1 and sestrin-2, resulting in the induction of Nrf2-target genes [278]

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