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It is also possible that in active acromegaly, chronic exposure to elevated IGF-I levels resets IGF-IR responsiveness via the induction of IGF-IR resistance (70), as it has been demonstrated that prolonged stimulation with IGF-I induces functional IGF-IR resistance in vitro through the negative feedback loop (72)

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Diabetes Care, 43(6), 1352-1355

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in contrast, we did not observe demyelination in anterior regions (Supplementary Fig

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