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Under pathological conditions, they may initially exert neuroprotective effects, yet prolonged activation often results in metabolic disturbances and neurotoxic gliotransmission, highlighting their dual role in CNS pathology and their potential in therapy [293]
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Increases in the accumulation of reactive oxygen species are related to polymorphisms in antioxidant enzymes such as glutathione peroxidases and glutathione S-transferases, which are linked to an increased risk of vascular disease
The gut microbiome may also influence the expression of genes associated with metabolism 2,5
