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encapsulated entacapone into PEGylated PLGA (PEG-PLGA@Ent) nanoparticles and nanostructured lipid carriers (NLCs) to enhance its bioavailability and pharmacological efficacy while mitigating its limitations, such as low oral bioavailability and rapid clearance 130

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Adsorption Within Mesopores The simplest and most extensively used loading approach is physical adsorption

The identity of selected ions was confirmed by comparison of retention time and MS 2 spectra between the QC pool and analytical standards

Both compounds require subcutaneous administration for bioavailabilityoral forms degrade rapidly in gastric acid and hepatic first-pass metabolism