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Beta-3 adrenergic receptor downregulation is theoretically possible with chronic agonist exposure, but clinical data on AOD-9604 shows minimal tachyphylaxis over 12-week protocols

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2.5 mg of tirzepatide is 25 units on a U-100 insulin syringe at the common 10 mg/mL concentration (a 10 mg vial in 1 mL of bacteriostatic water)