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Description
A lack of folic acid can manifested itself in the form of mucous membrane changes in the area of the oral cavity, gastrointestinal disorders with diarrhea, macrocytic anemia, and a rise in homocysteine levels in the blood
doi: 10.1093/bioinformatics/btl183

Then, the frequency can be reduced as the patient gets better

Obesity: identification, assessment and management (CG189) scope reference
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