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This is supported by translational data indicating that blocking nitro-oxidative stress, inflammatory and neurotoxic pathways with selective antioxidative compouds may alleviate depressive-, anxiety-, and chronic fatigue-like behaviors [25, 26, 30, 35,36,37,38,39,40]

The lack of intrinsic factor is most commonly due to autoimmune gastritis, which causes an autoimmune attack on the parietal cells that create it in the stomach

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While IV therapy is highly effective because it delivers the antioxidant directly into the bloodstream, bypassing the digestive tract entirely, it is also expensive, invasive, and impractical for daily, long-term management

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors