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One of the hallmarks of the inactive X chromosome is the hypermethylation of promoter CpG islands along the length of the inactive X, which contributes to the stable maintenance of transcriptional silencing of the associated genes on the inactive X chromosome (72)

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An octapeptide (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe) complex was obtained by co-crystallisation of DAP BII (H86A/D224A/S657A triple mutant) with angiotensin II as a model peptide (octapeptide complex, Table S1)
