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Regardless, while the ferrohaem may not follow the same binding scheme as the ferrihaem, in either case the distal histidine and its protic environment is paramount as its absence in H64V Mb appears to interrupt the stepwise proton transfer(s), resulting in decreased NiR activity (Yi et al ., 2009)

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Sclocco R, Garcia RG, Kettner NW, Fisher HP, Isenburg K, Makarovsky M, Stowell JA, Goldstein J, Barbieri R, Napadow V (2020) Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation

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If the trucks don't get unloaded, the food sits there, ferments, and leads to that familiar, uncomfortable gas