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We also observed an increase in the 18 kDa translocator protein TSPO, which is a mitochondrial cholesterol-binding protein and upregulated in microglia during inflammatory activation associated with neurodegeneration (Fig

Using the 13 C 4 -octadepsipeptide ethyl ester as an example, MS fragmentation of the pseudomolecular ion ( m/z 841.5, [M+Na] + ) revealed specific fragment ions for the hexadepsipeptide L- O -Val-L-Val-D- O -Leu-D-Ala-L- O -Val-L-Val ( m/z 841.5 [M+Na] + 628.3, 528.2 [M+K] + ) released after cleavage of D- O -Leu-D-Ala (Fig

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