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Studies have indicated that Methylcobalamin can help improve symptoms of neuropathy and other neurological disorders more effectively than cyanocobalamin

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When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted

This process can be slow and inefficient, and people with absorption problems may take in far less of an oral dose than a healthy person would

Scale is defined by bioavailability , not quantity