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While less common than IV or IM methods, it offers unique advantages: Easier self-administration than IM injection (smaller needle, less painful) Slower, sustained absorption over 14 hours Lower bioavailability (~7085%) compared to both IV and IM Best suited for lower maintenance doses (up to 600mg per injection site) Most clinicians recommend IM injection over subcutaneous for skin whitening because the higher bioavailability and faster absorption from muscle tissue produce more consistent results