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To also test the maximal possible increase in efficacy of the two drugs when given together, we administered single injections of 4 ml with increasing doses of L838,417 and a constant dose of CLP257 (100 mg kg 1 )
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Researchers investigate how selective NNMT inhibition affects cellular processes under controlled laboratory conditions
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The researchers observed that FOXO4 transitions into the nucleus following the induction of the senescence in the cell
