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And so that's what I'm taking away from what you're saying is that we need to go through different types of intermittent challenge and we are rewarded with particular compounds that are reparative, both for the challenge but then make us stronger

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Among the compounds synthesized, we highlight compounds 7 (IC 50 = 0.084 M), 8 (IC 50 = 0.102 M), and 9 (IC50 = 0.064 M), which are good inhibitors and meet the criteria of Lipinski's rules for oral administration as drugs (Figure 6)