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Genes involved in thioredoxin biosynthesis (MGG_04236), recycling (TRR1) and use (TPX1) were also downregulated in tps1 compared to WT strains on GMM with nitrate

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These results suggest that metformin exerts its antioxidant effects through the modulation of Trx and the subsequent activation of the AMPK-FOXO3 pathway, providing a mechanistic understanding of metformins antioxidative properties in human endothelial cells (Hou et al., 2010)

All human specimens were procured and analyzed after obtaining written informed consent with the approval of the Ethics Committees of Graduate School of Medicine, Kyoto University (G562)
