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Description
When mitochondria are impaired in some physiological or pathological conditions with mtDNA damage and mitochondrial dysfunction, mitophagy can remove damaged mitochondria to maintain cell homeostasis
As free radicals cause oxidative damage to biological macromolecules, such as DNA, lipids, and proteins, they are believed to be involved in the pathogenesis of many diseases 16
Sangwan, V
& Scott, T
Furthermore, the substituted xanthine molecule has been used as a scaffold to synthesize new drug-like compounds as a non-dopaminergic strategy for neuroprotection 16
