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Compared with the cecal metabolome of untreated mice, the levels of primary bile acids (especially taurocholic acid (TCA)), carbohydrates, and sugar alcohols were elevated, while the levels of bacterial metabolites (secondary bile acids and carboxylic acids) were decreased (Gutierrez et al., 2020)

Nat Clin Pract Oncol (2007) 4(1):3041

Together these data suggest that DP cells are resistant to the activity of Rspondins, Dkk2 and Notum , and matrix cells are the cellular target for these agonists and antagonists

That said, functional medicine thrives on looking at early evidence, asking good questions, and integrating therapies when benefits may outweigh risks

ERJ Open Res