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Participants were splits into two groups

Consistent with this, our RNAseq analysis revealed significant alterations in the expression of genes involved in glutathione metabolism following melatonin treatment ( Figure 6A )

In summary, we have applied, for the first time, an untargeted adductomics approach in a setting of DNA repair deficiency, uncovering novel endogenous DNA adducts that are likely to contribute substantially to mutagenesis

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