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This was with taking no B12 supplements at all for 12 months

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Although a possible neurotransmitter role was claimed, i.e., for prostaglandins [144,145,146,147] and somatostatin [148,149,150], this was not combined with the cytoprotective effect and possible pleiotropic effect (organoprotection)

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The homocysteine concentration provides information on whether the intracellular methionine cycle is functioning (which depends on B vitamins), whereas MMA documents specifically the effectiveness of B 12 dependent reactions