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Co-treatment with the antioxidant N-acetylcysteine (NAC), a ROS scavenger 45 , abolished the Molidustat-induced ROS increase, supporting a functional link between GSTP1 inhibition and redox imbalance (Supplementary Fig

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We are grateful to members of the Myant and von Kriegsheim laboratory for their discussions and critical reading of the manuscript

Dpantethine affected numerous proteins involved in phospholipid remodeling, and granule protein cargo was also altered, pointing toward changes in vesicle origin or activation state

Rose S, Melnyk S, Pavliv O, Bai S, Nick T, Frye R, James S