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doi: 10.1038/s41380-019-0414-4 216 GolimbetVEKorovatsevaGIGabaevaMVVelikaiaNVSnegirevaAAKasparovSVet al

doi: 10.1016/j.peptides.2019.170171

Sunitinib but Not VEGF Blockade Inhibits Cancer Stem Cell Endothelial Differentiation

Important Safety Reminders Medical Supervision Required: AOD-9604 should only be used under qualified medical supervision Baseline and monitoring laboratory testing is recommended Individual contraindications and health status must be evaluated AOD-9604 is not FDA-approved for any indication Contraindications and Precautions: Pregnancy and breastfeeding (no safety data available) Active malignancy (discuss with oncologist) Pediatric use (not studied in children) Significant organ dysfunction (limited safety data) Report Concerns: Any unexpected symptoms or adverse effects should be reported to your healthcare provider promptly

The descent of fat and skin due to the loss of facial volume and elasticity contributes to this condition, further exacerbating the situation
