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These mechanisms underscore the dual nature of ferroptosis in PDAC, acting as both a suppressive and a tumor-promoting force depending on the context (66)

We cannot prevent or predict every interaction, and the science is clear that most exposureseven common onesonly raise risk slightly

J Pineal Res 46:17 Jensen NB, Ottosen CO, Zhou R (2023) Exogenous melatonin alters stomatal regulation in tomato seedlings subjected to combined heat and drought stress through mechanisms distinct from ABA signaling

The alkoxyl radical cyclizes to form an epoxyallylic radical

It is possible that, similar to other biomolecules and compounds, Zn shows cell type-, concentration-, and disease stage-dependent effects, which makes it mandatory to utilize appropriate supplementation strategies for specific contexts rather than making absolute recommendations [111]