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Interestingly, higher levels of baseline MG derivatives in the serum were associated with a faster rate of cognitive decline in ederly individuals, indicating that peripheral MG metabolism imbalances may also affect brain pathopysiology (Beeri et al., The functional defense role of the glyoxalase pathway has been exploited as a potential therapeutic target, through strategies aiming at reducing MG concentrations and/or enhancing the glyoxalase system in brain diseases

10.3390/molecules21111494 80 KalyaniN.GoelS.JaiswalS

In longevity practice, that result deserves attention, because it can be an early sign of metabolic strain, alcohol effect, recovery overload, or liver stress that has not yet shown up as disease

D.SennhennP.et al (2023)

Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells