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Guanine has the lowest redox potential among the four bases, making it more susceptible to be damaged from oxidative stress and form 8-oxoG

doi: 10.1074/jbc.271.14.8373
These mitochondrial perturbations can stimulate intrinsic apoptosis pathways
Protein was precipitated with 50 L of 35 % (v/v) perchloric acid, and the mixture was centrifuged at 2800 g for 10 min

As study progressed, scientists corrected their view, acknowledging the similarities but also pointing out the differences between these two anatomical sites
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