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105 Neoalbaconol down-regulates E3 ubiquitin ligases cellular inhibitors of apoptosis protein 1/2 (cIAP1/2) and TRAFs to abolish K63-linked ubiquitination on RIPK1

Perspective of the MCL disease space, unmet need and experience as a BRUIN study investigator

Excess conjugate and unbound sample or standard are washed from the plate, and Avidin conjugated to Horseradish Peroxidase (HRP) is added to each well and incubated

At the same time, a poly(lactic-co-glycolic acid) (PLGA) nanovaccine co-delivering the adjuvant R837 and Luc-4T1 cell membrane antigen, with surface-exposed calreticulin, can induce active uptake by DCs thereby enhancing the anti-tumor effect (101)

Sabbatini M, Bona E, Novello G, Migliario M, Reno F