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Additional in-vitro and in-vivo research is necessary to isolate the pure BCSO compounds in order to confirm the main constituents responsible for anti-inflammatory properties and the precise mechanisms of the action, particularly at the level of cellular death

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

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In addition to arrested growth, senescent cells were found to secret numerous pro-inflammatory cytokines, chemokines, growth factors, and proteases (known as senescence-associated secretory phenotype or SASP) [218]

9 , 10 GSH primarily protects cells from oxidative stress by neutralizing reactive oxygen and nitrogen species