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IBD includes a spectrum of disorders such as Crohn's disease and ulcerative colitis (UC), representing chronic remittent or progressive conditions determined by non-specific inflammation and intestinal tissue damage

To achieve a therapeutic breakthrough in TBI, multifaceted approaches are probably required, including the development of new clinically relevant models, refinements of established models and functional tests, consideration of systemic insults and multimodality monitoring, identification of specific and sensitive biomarkers, and optimization of therapeutic dosing and timing of single and combination treatments, as well as improvement in clinical trial design and operation

Ulfenborg B

Fedwick et al