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Any pathological process that can disrupt these interconnected metabolic hubs, such as mitochondrial dysfunction in PD or oxidative stress in AD, may inadvertently lower the cellular threshold for resistance to ferroptosis

PMID: 41046783 Redox Biol Deficiency of muscle-generated brain-derived neurotrophic factor causes inflammatory myopathy through reactive oxygen species-mediated necroptosis and pyroptosis

doi: 10.1038/s41598-020-65852-x

The limitation regarding the application of Exos in ferroptosis-targeted strategies lies in the incomplete understanding of how Exos regulate ferroptosis

(Landmark Ed.) 2025;30(3):26142