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Glutathione, being a strong antioxidant with additional anti-melanogenic properties, has recently become the most popular systemic skin lightening molecule

In addition, exercise activates the AMPK signaling pathway, accelerating fatty acid -oxidation, effectively reducing hepatic lipid accumulation, and improving blood lipid profiles, as evidenced by increased HDL levels and decreased LDL levels (Bekheit et al., 2025)

However, in addition to extracellular Zn regulating Ca 2+ gradients, intracellular Zn pools also affect Ca 2+ mobilization [3,12,27]

Negative emotions in response to the tumor and the interplay between the immune, neural and psychological systems may lead to anxiety and depression in patients with glioma, and anxiety and depression have been reported to shorten the survival time in such patients (89,94,95)