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The deprotonated forms of Lys and Arg with lower pKbs are much stronger bases than the deprotonated form of His, so at physiological pH, they would always be protonated (unless their local environment lowers their pKa and pKb values)

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325 The expression of OSKM leads to extensive remodeling of chromatin, accompanied by alterations of epigenetic enzymes and other transcription factors

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Organisms also regulate ROS generation

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10.1016/j.biopha.2019.109078 131 MaJ.XiaP.ZhouY.LiuZ.ZhouX.WangJ.et al (2020)

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