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It seems, that regarding changes and reduction in gene expression related to mitochondrial biogenesis and dynamics, the impact on an organisms fitness and health depends on various factors, such as the specific genes involved, the type of change, and the organisms environment
Bovine herpesvirus 4-based vector delivering the full length xCT DNA efficiently protects mice from mammary cancer metastases by targeting cancer stem cells
doi: 10.1038/nrm3496
This means that rare adverse effects occurring outside controlled trial settings would not be systematically documented
(2018) 25:35543563.e4
