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Similarly, a metaanalysis confirmed significant reductions in blood pressure, total cholesterol, LDLC, serum glucose, HbA1c, and BMI alongside increased HDLC levels [138]
Collectively, these results suggest that lactate mediates metabolism-induced epigenetic reprogramming in GBM that contributes to CD47-dependent immune evasion, which can be leveraged to augment efficacy of immuno-oncology therapies
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Evolutionary pressures and potential mechanisms
