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437 In a cohort study on non-frail elderly (mean age 82) men and women with atrial fibrillation in Norway, researchers showed that both standard and low-dose DOACs had a similar risk profile in regard to strokes and clots compared to warfarin, with a similar or decreased risk of bleeding issues
By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl sink, increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NAD
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