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While our findings of neurochemical abnormalities in the pgACC and dACC, in ME/CFS and long COVID patients are intriguing, they must be viewed with caution given the limitations of the study

Changes associated with a decrease in short chain fatty acids, such as butyrate, and disruption of intestinal barrier function leading to systemic inflammation has also been described [124]

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15 Meanwhile, chronic inflammation driven by intestinal permeability and autoimmunity, and other factors like processed food16and poor sleep, 17 may suppress thyroid activity