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Description
The conversion of glucose to fructose involves the polyol pathway where glucose is first reduced to sorbitol via the action of the aldose reductase encoded by the AKR1B1 (aldo-keto reductase family 1 member B) gene

However, patients in APOLLO were more likely to have high-risk cytogenetics, defined as presence of del(17p), t(14;16), or t(4;14), although cutoff levels were not reported

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Semaglutide can cause certain side effects in some patients which are usually mild
