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The absence of serious adverse events, treatment-related withdrawals, IGF-1 elevation, glucose metabolism impairment, or immunogenic responses represents a favorable safety foundation

Administering the Injection Choose the Injection Site : IM Injection Sites : Common sites include the deltoid muscle (upper arm), gluteus maximus (buttocks), and vastus lateralis (thigh)

IM injections go into muscle, most often the outer thigh (vastus lateralis) or deltoid

BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia

No trials specifically enrolled elderly individuals, those with significant cardiovascular disease, individuals with active cancer, or pregnant/breastfeeding women